Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke - PubMed
a day ago
- #ischemic stroke
- #antithrombotic therapy
- #atrial fibrillation
- Study focused on temporal patterns of antithrombotic therapy and clinical outcomes after atrial fibrillation-related stroke.
- Multicenter prospective cohort study in South Korea with 2965 patients (mean age 75.3 years, 54.1% male).
- Primary outcome was a composite of recurrent stroke, myocardial infarction, and all-cause death.
- Secondary outcomes included individual components of the primary outcome and major bleeding events.
- Antithrombotic strategies varied widely in the acute phase, with 50.9% receiving antiplatelet-only therapy initially.
- By discharge, non-vitamin K antagonist oral anticoagulant (NOAC) monotherapy became the predominant treatment (65.7%).
- Incidence of the primary endpoint was highest in the first 2 weeks (32.70 per 100 person-months) and declined thereafter.
- Patients on NOAC monotherapy had lower incidence rates compared to antiplatelet-only or no therapy.
- Early treatment strategies were heterogeneous but evolved toward NOAC monotherapy, with marked outcome differences.