Targeting the ferritinophagy axis: multi-target regulation of TFRC/FTH1/NCOA4 by artesunate ameliorates salivary gland dysfunction in Sjögren's Disease - PubMed
7 hours ago
- #Artesunate
- #Sjögren's Disease
- #Ferroptosis
- Artesunate (ART) improves salivary gland function in Sjögren's Disease (SJD) by targeting the ferritinophagy axis (TFRC/FTH1/NCOA4).
- ART reduces inflammatory infiltration and increases saliva flow in SJD model mice.
- ART suppresses ferroptosis by downregulating TFRC, upregulating FTH1, and reducing NCOA4 and LC3-II/I.
- Molecular docking suggests ART binds the FTH1-NCOA4 interface, potentially inhibiting ferritin degradation.
- ART also upregulates GPX4 and xCT, enhancing antioxidant defense against ferroptosis.
- The study supports ART as a novel therapeutic for SJD by targeting ferroptosis pathways.