Targeting the medial prefrontal cortex with transcranial temporal interference stimulation (tTIS) alleviates chronic pain - PubMed
9 hours ago
- #Preclinical Research
- #Chronic Pain
- #Neuromodulation
- Transcranial temporal interference stimulation (tTIS) applied to the medial prefrontal cortex (mPFC) effectively reduces chronic pain in a mouse model.
- Continuous tTIS in awake mice yields stronger and longer-lasting pain relief than intermittent stimulation or application under anesthesia.
- Stimulation duration and envelope frequency are the key parameters influencing analgesic efficacy, contributing 39.58% and 31.45% to the treatment effect, respectively.
- The optimal tTIS protocol involves continuous stimulation in awake mice at 0.05 mA, frequencies of 2000/2020 Hz, for 20 minutes, with effects lasting several days.