Interleukin-17 plays a crucial role in atopic Dermatitis-Associated Blood-Brain barrier disruption and cognitive impairment - PubMed
6 hours ago
- #Interleukin-17
- #Atopic Dermatitis
- #Blood-Brain Barrier
- Atopic dermatitis (AD) is linked to central nervous system (CNS) issues like cognitive decline and emotional disturbances.
- AD-like skin inflammation in mice causes BBB disruption, neuroinflammation, and behavioral abnormalities such as anxiety and cognitive deficits.
- IL-17 signaling is identified as a key factor in AD-associated BBB disruption and cognitive impairment.
- Inhibition of IL-17A with an antibody improves skin condition, reduces BBB disruption, suppresses neuroinflammation, and rescues behavior in mice.