Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs-Macrophage Crosstalk - PubMed
5 hours ago
- #Periodontitis
- #Nanoparticle
- #Inflammation
- Charge-adaptive nanoparticle (CPS@BA) targets and neutralizes neutrophil extracellular traps (NETs).
- CPS@BA dynamically switches charge from negative to positive in acidic inflammatory environments to capture NETs.
- The nanoparticle reverts to negative charge at neutral pH, reducing cytotoxicity.
- CPS@BA inhibits further NETs formation by releasing BAPTA-AM (BA), which chelates intracellular Ca2+ and blocks PAD4 activation.
- Disrupts NETs-macrophage crosstalk via the CXCL3-CXCR2 axis, reducing inflammation and bone resorption in periodontitis.
- Potential application in treating DNA-driven inflammatory diseases.