Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis - PubMed
5 hours ago
- #stem cell aging
- #DNA damage
- #clonal hematopoiesis
- Endogenous formaldehyde causes hematopoietic stem cell (HSC) attrition and clonal hematopoiesis (CH).
- Formaldehyde detoxification and Fanconi anemia (FA) DNA repair are crucial for HSC maintenance.
- Mice lacking formaldehyde protection showed initial polyclonal hematopoiesis, which later became monoclonal.
- Similar monoclonal hematopoiesis transition was observed in FA children.
- DNA damage-induced attrition can drive CH independently of fitness-enhancing selection.