Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early Legionella infection - PubMed
6 hours ago
- #SetA structure
- #Legionella infection
- #Rab1 glucosylation
- SetA, a bacterial effector protein from Legionella pneumophila, glucosylates the host GTPase Rab1, disrupting vesicle trafficking.
- Structural studies show SetA specifically recognizes GDP-bound Rab1 and binds to PI3P, enriched on early Legionella-containing vacuole membranes.
- SetA integrates Rab1 modification with PI3P-dependent membrane targeting to perturb Golgi integrity and ER morphology during early infection.