Memory reactivation underlies experience-dependent adaptive regulation of sleep - PubMed
4 hours ago
- #engram circuits
- #memory reactivation
- #sleep regulation
- Memory reactivation during sleep consolidates recent memories.
- Negative memory reactivation promotes arousal and can lead to sleep disturbances.
- Positive memory reactivation supports sleep stability.
- This regulation is mediated by hippocampus-amygdala engram circuits specific to the experience.
- In chronic stress models, suppressing negative memory reactivation can restore normal sleep.
- The findings establish a memory-dependent mechanism for sleep regulation based on memory content.