Mitochondrial protein OPA3 sustains cardiac function by regulating calcium handling in male mice - PubMed
4 hours ago
- #Calcium Handling
- #Mitochondrial Protein
- #Heart Failure
- OPA3 protein is reduced in human and mouse heart failure, and its loss in male mice leads to dilated cardiomyopathy with impaired cardiac function.
- OPA3 interacts with phospholamban (PLN) to regulate SERCA2a activity and calcium cycling, linking mitochondrial and sarcoplasmic reticulum function.
- Overexpression of OPA3 improves cardiac dysfunction in heart failure models, highlighting its potential as a therapeutic target.