Gut microbiota and bone aging: Focusing on the gut-X axis modes - PubMed
12 hours ago
- #Bone aging
- #Gut-X axis
- #Gut microbiota
- Gut microbiota plays a significant role in bone aging-related diseases like osteoporosis, osteoarthritis, and intervertebral disc degeneration.
- Potential mechanisms of the gut-X axis include neuromodulation, immunomodulation, endocrine regulation, metabolite-mediated regulation, bacterial extracellular vesicles, and changes in microbial niche.
- Intervention strategies such as diet, probiotics, fecal microbiota transplantation, and physical activity are summarized for clinical translation.
- The review introduces the integrated concept of 'gut-X axis' to explore common mechanisms underlying 'gut-bone axis', 'gut-joint axis', and 'gut-disc axis'.
- The translational potential of targeting the gut-X axis could expand research and clinical applications for bone aging-related diseases.