Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications - PubMed
14 hours ago
- #pregnancy complications
- #NFAT signaling
- #uNK cells
- Uterine natural killer (uNK) cells are crucial for successful pregnancy.
- Human uterus transplant (UTx) recipients showed reduced tissue-resident uNK cells compared to healthy controls.
- Loss of uNK cells in UTx recipients was linked to pregnancy complications like preeclampsia and placental vascular malperfusion.
- Single-cell RNA sequencing revealed impaired NK cell tissue residency programming due to NFAT signaling inhibition.
- NFAT inhibition, such as by tacrolimus, down-regulated adhesion molecules in uNK cells.
- NFAT-dependent genes regulate uNK cell residency programs involving AP-1 transcription factors and TGF-β-mediated integrin upregulation.