Sex-specific considerations in migraine therapy - PubMed
2 days ago
- #Sex Hormones
- #Precision Medicine
- #Migraine Therapy
- Migraine disproportionately affects women with higher prevalence, frequency, and disability compared to men.
- Sex hormones, particularly estrogen fluctuations, significantly influence migraine pathophysiology and severity.
- The role of hormonal status in treatment efficacy remains poorly studied and represents a critical research gap.
- This review discusses sex-specific responses to pharmacological therapies and hormone-based interventions like contraceptives and hormone replacement therapy.
- Special attention is given to female-specific migraine phenotypes, including menstrual migraine, across the reproductive lifespan.
- The review identifies major research gaps and underscores the need for sex- and gender-stratified approaches to optimize migraine treatment and advance precision medicine.