Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study - PubMed
6 hours ago
- #dementia risk markers
- #functional decline
- #aging trajectories
- Frailty, grip strength, and gait speed show distinct decline trajectories up to 11 years before dementia diagnosis.
- Dementia cases exhibited higher and steeper increases in frailty and faster declines in grip strength and gait speed compared to matched controls.
- Significant differences between cases and controls emerged 4-6 years before dementia onset, with gait speed being the earliest indicator.
- Functional declines were more pronounced in females and, to a lesser extent, in ApoE ε4 non-carriers.
- The study supports using functional measures like gait speed as early markers for dementia risk and targeted monitoring.