Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks - PubMed
4 hours ago
- #white matter
- #neurostimulation
- #brain networks
- Deep brain stimulation (DBS) targeting white matter near the subcallosal anterior cingulate cortex (SCC-DBS) in macaques increases fractional anisotropy in the cingulum bundle.
- At the cellular level, SCC-DBS is associated with increased myelinated oligodendrocytes and enhanced myelination in the mid-cingulum bundle.
- SCC-DBS alters brain-wide functional connectivity, particularly affecting interactions between the SCC and networks like the default mode network, which is implicated in depression.
- The findings suggest that white matter remodeling and changes in brain networks may contribute to DBS's therapeutic efficacy for neurological and psychiatric disorders.