ZNF219 inhibits porcine epidemic diarrhea virus by degrading viral S2 protein - PubMed
5 hours ago
- #ZNF219
- #PEDV
- #autophagy
- ZNF219 inhibits porcine epidemic diarrhea virus (PEDV) by degrading the viral S2 protein.
- PEDV significantly impacts the global agricultural economy, and current vaccines are insufficient against emerging strains.
- ZNF219 is upregulated by viral nonstructural protein 12 (nsp12) during PEDV infection.
- ZNF219 recruits TRAF6 to ubiquitinate the PEDV S2 protein, leading to its degradation via selective autophagy.
- The ubiquitinated S2 protein is recognized by p62 and degraded in autolysosomes, inhibiting PEDV replication.
- This study reveals a novel antiviral mechanism involving ZNF219 and suggests a new target for PEDV treatment.