Development and validation of clinical criteria for the definition of disease activity in adult-onset Still's disease: a cohort study - PubMed
5 hours ago
- #Adult-onset Still's disease
- #Clinical validation
- #Disease activity criteria
- Study aimed to develop and validate clinical criteria for assessing disease activity in adult-onset Still's disease.
- Data from GIRRCS cohort (187 patients) and CONSIDER trial (41 patients) were used for development and validation.
- Selected criteria include fever, skin rash, arthritis, patient global assessment ≥2 cm, and CRP >10 mg/L.
- Active disease defined as fever plus one other criterion, or no fever with at least three other criteria.
- Low disease activity defined as no fever and no more than one criterion.
- Clinically inactive disease defined as absence of all five criteria.
- Performance of criteria was validated with high AUROC values across cohorts.