Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis - PubMed
2 days ago
- #Choroid Plexus
- #MRI
- #Multiple Sclerosis
- Study investigates the relationship between choroid plexus (ChP) gadolinium enhancement and brain tissue injury in multiple sclerosis (MS).
- 34 MS participants and 21 healthy controls underwent 7T MRI, including MP2RAGE and FLAIR acquisitions.
- MS participants showed higher mean qT1 values in ChP, normal-appearing white matter (NAWM), and gray matter (GM) compared to controls.
- ChP enhancement (ΔT1) was significantly associated with pre-gadolinium qT1 values in NAWM and GM, but not with white matter lesion (WML) volume or qT1.
- Findings suggest a CSF-mediated toxicity mechanism in MS brain injury, distinct from classic lesion pathology.