Effects of Disulfiram and Copper in Combination with Temozolomide on Survival, Tumor Size and Autophagy Markers in an F98 Rat Glioma Model - PubMed
5 hours ago
- #temozolomide
- #glioblastoma
- #autophagy
- Glioblastoma (GBM) is an aggressive brain tumor with a median survival of 15 months.
- Temozolomide (TMZ) resistance in GBM is linked to autophagy.
- Disulfiram (DSF) with copper (Cu) shows anti-GBM activity and re-sensitizes tumors to TMZ.
- Study tested DSF-Cu with TMZ in Fischer rats with F98 glioma, a TMZ-resistant model.
- TMZ-DSF-Cu combination increased survival and induced autophagy markers LC3 and p62.
- Results highlight the necessity of Cu for DSF's efficacy in sensitizing glioma to TMZ.