Current and emerging approaches to manage chronic inflammatory gut disorders - PubMed

7 hours ago

Chronic inflammatory gastrointestinal disorders like IBD, Crohn's disease, ulcerative colitis, and IBS are difficult to manage due to complex causes and varied disease progression.
Current diagnostic and therapeutic strategies include invasive and non-invasive tools, symptomatic control, pharmacotherapy, and surgery, but often fail to achieve sustained remission.
Nanomedicine is emerging as a promising approach for targeted drug delivery and improved therapeutic efficiency, though challenges like biosafety and scalability remain.
Living diagnostic-therapeutic systems, such as engineered whole-cell sensors, offer real-time sensing and therapeutic response in the gut, showing potential in preclinical studies.
Key challenges for living systems include biosensor functionality, genetic stability, microbial colonization, and integration into healthcare frameworks.
The combination of nanomedicine and living systems could revolutionize the diagnosis and treatment of chronic inflammatory gut diseases.

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