Olfactory cleft biopsy analysis of Alzheimer's disease pathobiology across disease stages - PubMed
5 hours ago
- #Alzheimer's Disease
- #Olfactory Biopsy
- #Neuroinflammation
- Olfactory cleft biopsy analysis reveals early pathobiological changes in Alzheimer's Disease (AD).
- Single cell RNA-sequencing shows neuroinflammatory T cell, myeloid cell, and olfactory neuron changes in pre-clinical AD.
- Activated memory T cell states in the olfactory epithelium are a hallmark of pre-clinical AD.
- Findings provide a platform for analyzing neural tissue in AD at its earliest stages.
- Competing interests include patent applications related to olfactory cleft biopsy methods for AD diagnosis.