LRRC71 is essential for sperm motility, fertilization and male fertility - PubMed
4 hours ago
- #sperm motility
- #male infertility
- #LRRC71
- LRRC71 is essential for sperm motility, fertilization, and male fertility in mice, and its knockout leads to asthenozoospermia.
- LRRC71 knockout disrupts mitochondrial sheaths in sperm, impairing both glycolysis and oxidative phosphorylation pathways, resulting in reduced ATP content.
- LRRC71 knockout sperm show defective fertilization capacity and fail to migrate into the oviduct, with down-regulation of key metabolic and fertilization-related proteins.
- A novel heterozygous variant of LRRC71 was identified in an asthenozoospermia patient, highlighting its potential clinical relevance in male infertility.
- Despite failed in vitro fertilization, successful intracytoplasmic sperm injection was achieved in LRRC71 knockout mice, suggesting it as a diagnostic and therapeutic target.