Total marrow and lymphoid irradiation in combination with cyclophosphamide and etoposide before haematopoietic cell transplantation for relapsed or refractory acute leukaemia: a single-centre, open-la
6 hours ago
- #conditioning regimen
- #hematopoietic cell transplantation
- #relapsed acute leukemia
- This phase 2 trial assessed total marrow and lymphoid irradiation (2000 cGy to bone marrow and lymph nodes) combined with high-dose cyclophosphamide and etoposide as a conditioning regimen before allogeneic hematopoietic cell transplantation (HCT) for relapsed or refractory acute leukemia.
- The regimen was safely delivered and associated with a 2-year progression-free survival rate of 34% in 106 enrolled patients, with adverse events including cytopenias (91%), metabolic disorders (78%), and oral mucositis (42%).
- Total marrow and lymphoid irradiation allowed organ sparing, resulting in few adverse events; one patient died from sinusoidal obstruction syndrome attributed to the conditioning regimen.