Long-Term Outcomes and Safety of His-Purkinje Conduction System Pacing in China: The ChiCSP Study - PubMed
5 hours ago
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- The ChiCSP study evaluated long-term outcomes and safety of His-Purkinje conduction system pacing (CSP) in China.
- CSP includes His bundle pacing (HBP) and left bundle branch area pacing (LBBAP), offering a physiological alternative to conventional pacing.
- The study classified LBBAP into left bundle branch pacing (LBBP), left ventricular septal pacing (LVSP), and unclassified LBBAP based on capture certainty.
- Among 3,167 patients who successfully received CSP, LBBP showed the greatest LVEF improvements in patients with LBBB and heart failure with reduced ejection fraction.
- LVSP was associated with higher mortality or heart failure hospitalization compared to LBBP and unclassified LBBAP.
- Threshold increases were more common in HBP (5.03%) than LBBAP (1.80%).
- Procedural complications (excluding threshold rise) occurred in 1.3% of both HBP and LBBAP groups.
- The study concluded that CSP is safe and stable long-term, with LBBP yielding better clinical outcomes than LVSP.