Allostatic load in psychiatry: a systematic review and meta-analysis - PubMed
a day ago
- #psychiatry
- #meta-analysis
- #allostatic-load
- The allostatic load (AL) model assesses multisystem dysregulation in psychiatric disorders using biomarkers.
- A systematic review and meta-analysis found elevated AL in individuals with psychiatric disorders compared to healthy controls.
- Higher AL was specifically noted in schizophrenia and first-episode psychosis (SMD: 0.97; 95% CI: 0.76, 1.18; p < .0001).
- No significant difference in AL was found for major depressive disorder (SMD: 0.07; 95% CI: -0.23; 0.37; p = 0.67).
- The AL model is a valuable tool for evaluating chronic stress impact across biological systems and aiding early intervention.