The emerging role of kinase fusion proteins in cereal immunity - PubMed
4 hours ago
- #Kinase fusion proteins
- #Cereal crops
- #Plant immunity
- Kinase fusion proteins (KFPs) are emerging as important intracellular plant immune receptors in wheat and other Triticeae members.
- KFPs consist of at least one kinase domain fused to additional domains, possibly including another kinase domain.
- Many KFPs feature an atypical structural motif called the extended β-finger, suggesting shared mechanisms in plant immunity.
- Specific KFPs like SR62TK from Aegilops sharonensis and RWT4 (allelic to PM24) from wheat act as primary receptors, initiating immune signaling by recruiting NLR proteins.
- KFPs exhibit structural and functional diversity, with evolutionary significance and potential for engineering durable disease resistance in crops.