High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis - PubMed
5 hours ago
- #meta-analysis
- #influenza vaccine
- #older adults
- High-dose influenza vaccine (HD-IIV) shows superior protection compared to standard-dose vaccine (SD-IIV) in older adults (≥65 years).
- Meta-analysis of 8 randomized trials with 605,098 participants finds HD-IIV significantly reduces hospitalizations for influenza (38.5% relative vaccine effectiveness), lab-confirmed influenza (31.2%), pneumonia/influenza (11.5%), cardiorespiratory disease (7.5%), and all causes (3.3%).
- No significant difference in all-cause mortality between HD-IIV and SD-IIV was observed.
- Results were consistent across subgroup analyses, including age and cardiovascular disease status.
- Findings support HD-IIV use to prevent hospitalization outcomes, informing vaccine recommendations and policies.