Patients with Ehlers-Danlos syndrome experience reduced effectiveness of lidocaine local anesthetic: a randomized cross-over clinical trial - PubMed
5 hours ago
- #Anesthesia resistance
- #Lidocaine
- #Ehlers-Danlos syndrome
- Patients with Ehlers-Danlos syndrome (EDS) experience reduced effectiveness of lidocaine local anesthetic.
- A randomized cross-over clinical trial compared EDS patients (n=91) with healthy controls (n=44).
- Sensation tests post-lidocaine injection showed significant differences at 15 and 30 minutes, but not at 5 minutes.
- A smaller proportion of EDS patients experienced adequate anesthesia at 15 and 30 minutes compared to controls.
- The study validates previous reports of local anesthetic resistance in EDS patients.
- Healthcare providers should adjust care for EDS patients due to reduced lidocaine effectiveness.