Exosomal miRNA let-7i-5p alleviates asthma triggered by RSV-induced exosomes by regulating dendritic cell autophagy via the MITF/DAP1/P70S6K pathway - PubMed
6 hours ago
- #Asthma
- #Autophagy
- #Exosomes
- Exosomal miRNA let-7i-5p alleviates asthma triggered by RSV-induced exosomes.
- RSV infection is a significant trigger for asthma.
- Exosomes from BMSCs induced by RSV (Exos-RSV) can induce asthma.
- miRNA let-7i-5p is low in Exos-RSV and plays a key role in asthma.
- Overexpression of miRNA let-7i-5p in exosomes alleviates asthma symptoms.
- Exos-RSV lacking miRNA let-7i-5p increases inflammatory factors and lung tissue damage.
- miRNA let-7i-5p regulates dendritic cell autophagy via the MITF/DAP1/P70S6K pathway.
- Therapeutic potential of miRNA let-7i-5p in asthma treatment.