Engineered Bacteroides thetaiotaomicron sense gut inflammation and deliver therapeutic molecules to alleviate colitis in mice - PubMed
4 hours ago
- #Colitis treatment
- #Engineered bacteria
- #Gut inflammation
- Engineered Bacteroides thetaiotaomicron (Btbots) senses gut inflammation biomarkers (deoxycholic acid and nitric oxide) and delivers therapeutic molecules.
- Btbots were designed to either display trefoil factor-3 for mucosal repair or secrete interleukin-35 to suppress inflammation.
- In mouse models, Btbots alleviated colitis, modulated the gut microenvironment, and influenced the microbiota.
- The study demonstrates a proof of concept for localized sensing and therapeutic release in the gastrointestinal tract, with clinical potential requiring further investigation.