Difference in Respiratory Function Between GOLD Stage 1 and Preserved Ratio Impaired Spirometry as Assessed by Impulse Oscillometry and Spirometry - PubMed
5 hours ago
- #respiratory function
- #GOLD stage 1 COPD
- #PRISm
- PRISm (Preserved Ratio Impaired Spirometry) and GOLD stage 1 COPD show distinct respiratory-mechanical patterns despite overlapping spirometric profiles.
- Impulse oscillometry (IOS) revealed greater peripheral airway dysfunction in PRISm compared to GOLD 1, despite relatively preserved spirometric indices.
- Longitudinal changes in spirometry and IOS showed wide variability and no meaningful differences between PRISm and GOLD 1 groups.
- IOS identified peripheral airway abnormalities in PRISm not evident on spirometry, suggesting its potential value in early or atypical airway dysfunction detection.
- Study limitations include small sample size for PRISm, incomplete IOS data, and confounding factors like age, smoking status, and bronchodilator exposure.
- Findings are descriptive and hypothesis-generating, calling for larger prospective studies with comprehensive assessments to clarify IOS patterns' clinical relevance in PRISm.