Show HN: SubstanceWiki – Open-source encyclopedia of psychoactive substances
6 days ago
- #harm-reduction
- #drug-effects
- #psychoactive-substances
- SubstanceWiki is a comprehensive, evidence-based encyclopedia of psychoactive substances.
- Kratom (Mitragyna speciosa) is a tropical tree whose leaves contain alkaloids acting as partial mu-opioid agonists.
- Kratom is used for chronic pain, opioid withdrawal, and has potential antipsychotic and antidepressant properties.
- Psilocybin mushrooms contain psilocybin and psilocin, producing psychedelic effects via serotonin 5-HT₂A receptor agonism.
- Psilocybin has a long history of human use, with evidence dating back 7,000–9,000 years.
- Psilocybin is considered safe with no confirmed fatalities from toxicity alone and low harm potential.
- Diphenhydramine (Benadryl) is an antihistamine with sedative and anticholinergic effects, sometimes used recreationally.
- 2C-B is a synthetic psychedelic phenethylamine with dose-dependent effects ranging from empathogenic to fully psychedelic.
- LSD is a potent psychedelic with effects lasting 8–12 hours, primarily acting on serotonin 5-HT2A receptors.
- DMT is a powerful, short-acting psychedelic that induces intense, otherworldly experiences, often described as entering another dimension.
- Ayahuasca combines DMT with MAOIs to enable oral activity, extending the experience to 4–6 hours.