Symptom-based indicators of autonomic dysfunction and their bidirectional associations with Parkinson's disease incidence and adverse outcomes - PubMed
5 hours ago
- #Parkinson's disease
- #autonomic dysfunction
- #biomarkers
- Autonomic dysfunction symptoms like orthostatic hypotension, constipation, urinary and sexual dysfunction are common in Parkinson's disease (PD).
- These symptoms can serve as early biomarkers for PD detection and prognosis.
- A study of 374,657 UK Biobank participants found autonomic symptoms independently predicted PD risk.
- Orthostatic hypotension had the highest hazard ratio (HR 2.91) for PD risk, followed by sexual dysfunction (HR 3.56).
- Autonomic dysfunction was detectable over 10 years before PD diagnosis, with strongest association within 5 years after onset.
- Pre- and post-diagnostic autonomic dysfunction were linked to higher risks of PD dementia and mortality.
- The findings highlight the utility of autonomic symptoms for early risk stratification and long-term PD management.