Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk - PubMed
2 days ago
- #retroelements
- #placental-evolution
- #pre-eclampsia
- Endogenous retroviral elements LTR8B and MER65 influence PSG9 regulation, impacting trophoblast syncytialization and pre-eclampsia risk.
- LTR8B acts as a placentally-relevant cis-regulatory element (CRE) within the PSG array, affecting PSG9 and other PSG family members.
- PSG9 produces both secreted and membrane-anchored isoforms, with MER65-int providing alternative polyA signals for secreted variants.
- LTR8B/PSG9 regulates syncytiotrophoblast differentiation, similar to chorionic gonadotropin and syncytin1.
- PSG9 is the most upregulated PSG in pre-eclampsia (PE), with levels correlated with GATA3 and DLX5 dysregulation.
- PSG9 shows potential as a predictive biomarker for pre-eclampsia due to its first-trimester expression and association with DLX5/GATA3 dysregulation.