Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation - PubMed
5 hours ago
- #Hantaan virus
- #neutralizing antibodies
- #vaccine
- Prefusion-stabilized Hantaan virus (HTNV) glycoprotein nucleic acid vaccines (DNA and mRNA-LNP) elicit potent neutralizing antibodies in mice.
- The vaccines activate germinal centers strongly, providing protection against high-dose HTNV challenge.
- Heterologous prime-boost regimens with inactivated vaccine priming and prefusion-stabilized glycoprotein mRNA-LNP boosting show superior neutralizing antibody responses.
- The prefusion-stabilized glycoprotein-based vaccines demonstrate potential for next-generation orthohantavirus vaccine development.
- Authors have filed a provisional patent related to the vaccine design.