Molecular understanding and clinical aspects of adoptive cellular immunotherapy in prostate cancer - PubMed
4 hours ago
- #prostate cancer
- #CAR-T therapy
- #adoptive cellular immunotherapy
- Adoptive cellular immunotherapy (ACT) involves infusing activated autologous lymphocytes to target tumor cells.
- ACT has shown promise in hematologic malignancies but faces challenges in solid tumors like the immunosuppressive tumor microenvironment and adverse events.
- Recent advancements include CAR-T, TCR-T, CAR-NK, BiTEs, and CAR-M cells, which may improve safety and efficacy for solid tumors.
- Prostate cancer, especially metastatic castration-resistant PCa (mCRPC), often becomes treatment-resistant, making ACT a promising novel therapeutic approach.
- This review discusses the development and mechanisms of ACT strategies to support future therapy development for prostate cancer.