Kynurenine pathway impact on immune evasion and inflammation in acute myeloid leukemia - PubMed
3 hours ago
- #AML
- #kynurenine pathway
- #immune evasion
- The kynurenine pathway (KP) is central to immune dysregulation in acute myeloid leukemia (AML).
- Overexpression of IDO1 and TDO2 leads to excess L-kynurenine (Kyn), which activates AhR and promotes IL-6 secretion, STAT3 phosphorylation, and NF-κB activation, sustaining chronic inflammation.
- KP activation suppresses immunity by biasing T cells toward regulatory phenotypes, exhausting T and NK cells, and impairing dendritic and B-cell function, creating an immunosuppressive environment.
- While upstream KP enzymes are well-studied, downstream metabolites like KYNA, 3-HK, and QUIN are less characterized but may influence inflammation and T-cell apoptosis.
- The KP links chronic inflammation and immune tolerance in AML, impacting disease progression, immune escape, and resistance, warranting further research.