ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease - PubMed
5 hours ago
- #ACSS2
- #IBD
- #Crotonylation
- ACSS2-mediated lysine crotonylation (Kcr) attenuates senescence in adipose-derived stem cells (ADSCs).
- Senescent ADSCs show reduced Pan-Kcr levels; sodium crotonate (NaCr) treatment reverses senescence and enhances anti-inflammatory function.
- ACSS2 downregulation in senescent ADSCs is critical; NaCr promotes H3K9 crotonylation at the ACSS2 promoter, forming a positive feedback loop.
- ACSS2-Kcr suppresses the NF-κB pathway, delaying ADSC senescence and improving therapeutic efficacy in inflammatory bowel disease (IBD).
- Epigenetic modulation via Kcr is a novel strategy to enhance ADSC-based IBD therapy.