Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies
3 hours ago
- #mortality risk
- #anxiety disorders
- #suicide attempt
- Individuals with anxiety and stress-related disorders face a significantly higher all-cause mortality risk compared to the general population (RR=1.54).
- Suicide mortality risk is substantially elevated across these disorders, particularly for panic disorder (RR=3.58) and PTSD/stress-related disorders (RR=3.13).
- Risk of suicide attempt is notably increased, with panic disorder showing the highest risk (RR=6.33).
- Natural-cause mortality is higher in generalized anxiety disorder, mixed anxiety disorders, PTSD/stress-related disorders, and overall anxiety/stress disorders.
- Cardiovascular-related deaths are elevated in generalized anxiety disorder and mixed anxiety disorders, while cancer mortality risk is specifically increased only in generalized anxiety disorder.
- Publication bias exists across analyses, but sensitivity analyses largely support the main findings, emphasizing the need for more research on modifiable risk factors.
- The high global prevalence and treatment gap for anxiety disorders make these findings a significant public health concern, calling for improved prevention, screening, and treatment strategies.