O-GlcNAcylation regulates microglial neuroinflammation in Parkinson's disease - PubMed
5 hours ago
- #Parkinson's disease
- #O-GlcNAcylation
- #neuroinflammation
- O-GlcNAcylation reduction linked to neuroinflammation in Parkinson's disease.
- Elevating O-GlcNAcylation improved motor function and protected neurons in mouse models.
- Mechanism involves suppression of NF-κB signaling and pro-inflammatory cytokines.
- Findings suggest therapeutic potential for neurodegenerative disorders.