Impact of Basal Ganglia Perivascular Spaces on Ischemic and Hemorrhagic Risks in Patients Taking Antithrombotic Therapies - PubMed
4 hours ago
- #stroke
- #antithrombotic therapy
- #perivascular spaces
- Study assesses the impact of enlarged perivascular spaces (ePVSs) in the basal ganglia on hemorrhagic and ischemic risks in patients on antithrombotic therapy.
- Prospective, multicenter observational study in Japan with 5,065 patients (median age 74) taking antithrombotic agents.
- Basal ganglia perivascular spaces (BGPVSs) categorized into 0, 1-10, 11-20, or ≥21.
- Higher BGPVS burden (≥21) linked to increased risks of major bleeding (aHR 4.04) and ischemic stroke (aHR 2.58).
- No significant association found between BGPVS and ischemic events, intracranial hemorrhage, or mortality.
- BGPVSs may serve as imaging biomarkers for personalized vascular risk assessment in antithrombotic therapy.