The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities - PubMed
5 hours ago
- #Pre-metastatic niche
- #Metastasis
- #Extracellular vesicles
- Metastasis is the leading cause of cancer-related mortality.
- The pre-metastatic niche (PMN) helps tumors create favorable conditions in distant organs before metastasis.
- PMN hallmarks include immune suppression, vascular/lymphatic remodeling, metabolic reprogramming, and stromal reorganization.
- Origins of metastatic lesions involve circulating tumor cells (CTCs) and stromal stem-like cells.
- Extracellular vesicles (EVs) play a key role in intercellular communication and metabolic reprogramming.
- Understanding PMN biology can lead to early interception and treatment of metastasis.
- Therapeutic strategies targeting PMN include biomarker development, AI-assisted profiling, and immune/metabolic interventions.