Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes - PubMed
3 months ago
- #immunotherapy
- #dendritic cells
- #T cells
- Flt3L-mediated expansion of cDC1s enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes.
- Immune checkpoint blockade (ICB) reinvigorates T cell responses, with less differentiated cells showing better proliferation post-ICB.
- Combination of Flt3L and anti-CTLA-4 improves therapeutic responses and leads to oligoclonal expansion of CD8+ T cells in tumors.
- The mechanism depends on XCR1+ dendritic cells trafficking to tumor-draining lymph nodes and lymph node egress.
- Authors declare various research funding and patents related to the study.