Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections - PubMed
12 hours ago
- #Rheumatic heart disease
- #Mendelian randomization
- #Global burden
- Rheumatic heart disease (RHD) is a chronic valvular disorder caused by acute rheumatic fever, primarily affecting the mitral valve.
- The study uses the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021) to analyze RHD trends from 1990 to 2021 across 204 countries and territories.
- Key metrics analyzed include incidence, prevalence, disability-adjusted life-years (DALYs), and mortality, with variations by sex, age, and sociodemographic index.
- Two-sample Mendelian randomization identified high systolic blood pressure and high body mass index as causal risk factors for RHD.
- Findings show a slight increase in age-standardized prevalence and incidence rates but a decline in mortality and DALY rates.
- Projections suggest a continued rise in RHD incidence from 2022 to 2050, highlighting the need for targeted interventions.
- The study was funded by multiple grants from the National Natural Science Foundation of China and other organizations.