Mapping the scientific landscape of mitochondria-associated membranes: a bibliometric insight into emerging frontiers in aging and diseases - PubMed
5 hours ago
- #MAMs
- #aging
- #bibliometrics
- Mitochondria-associated membranes (MAMs) play a crucial role in energy metabolism, lipid homeostasis, and Ca2+ signaling, influencing cell survival and stress responses.
- Dysfunction in MAMs is linked to aging, neurodegenerative diseases, metabolic disorders, and cancer.
- A bibliometric analysis of MAMs-related literature from 2009 to 2024 identified 1199 publications with a rapid annual growth rate of 21.57%.
- Research hotspots include Ca2+ homeostasis, ER stress, apoptosis, and mitochondrial dynamics, with a shift toward aging-related processes.
- Key findings highlight aging, ER stress, and apoptosis as interconnected emerging themes, with specific MAMs-related proteins like HSP90α identified as regulatory hubs.
- The study provides an integrative bibliometric framework, linking publication trends with biological pathways and suggesting future research directions.