HSPA2 modulates antiviral immunity by inhibiting TBK1 activation - PubMed
6 hours ago
- #TBK1 inhibition
- #HSPA2
- #antiviral immunity
- HSPA2 negatively regulates type I interferon (IFN-I) production by inhibiting TBK1 activation, which is critical for antiviral immunity.
- Mechanistically, HSPA2 binds to TBK1 and competes with HERC5, blocking K63-linked ubiquitination of TBK1 at lysine 608.
- This disruption prevents TBK1 complex formation, IRF3 dimerization, and nuclear translocation, ultimately suppressing IFN-I production.
- The study, using Hspa2-deficient models, identifies HSPA2 as a potential therapeutic target for modulating antiviral responses.