Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10 - PubMed
5 hours ago
- #motor learning
- #astrocytes
- #synaptic plasticity
- Astrocytic MEGF10 is essential for eliminating corticostriatal excitatory synapses on medium spiny neurons (MSNs) during motor learning.
- Deletion of astrocytic Megf10 impairs long-term potentiation (LTP) and depression (LTD), reducing learning-induced synaptic strength increases.
- Chemogenetic activation of corticostriatal transmission or dopamine release enhances astrocytic synapse elimination.
- Dopamine and motor learning regulate postsynaptic elimination in MSNs based on dopamine receptor subtype, affecting synaptic remodeling.
- Astrocytic MEGF10 mediates dopamine- and activity-dependent synapse remodeling in the striatum.