Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in C. elegans - PubMed
6 hours ago
- #C. elegans
- #immunity
- #mitochondria
- PALS-22 and PALS-25 are immune regulators in C. elegans that localize to mitochondria.
- PALS-22 is a negative regulator, while PALS-25 is a positive regulator of immunity.
- PALS-25 is required for PALS-22's mitochondrial localization.
- The C-terminus of PALS-25 directs mitochondrial localization, and the N-terminus is required for signaling.
- Loss of PALS-22 causes mitochondrial fragmentation, which occurs after activating the intracellular pathogen response (IPR).
- Mitochondrial fragmentation increases resistance against microsporidia infection.
- PALS-22/25-mediated mitochondrial fragmentation enhances resistance against intracellular infection.