Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation - PubMed
5 hours ago
- #5-fluorouracil
- #stress hematopoiesis
- #hematopoietic stem cells
- Hematopoietic stem cells (HSCs) activate a latent differentiation pathway to aid recovery after 5-fluorouracil (5-FU)-induced myeloablation.
- Lineage tracing and mathematical modeling revealed a transient surge in HSC differentiation post-5-FU treatment, producing myeloid-biased multipotent progenitors (MPPs).
- HSC differentiation reverts to homeostatic patterns after the initial response to stress.
- MPPs significantly contribute to myeloid and lymphoid lineage regeneration following 5-FU challenge.
- The study identifies sequential fate transitions and stage-specific differentiation patterns of HSCs during stress hematopoiesis.