hnRNPA2B1 induces HBV cccDNA degradation by recruiting APOBEC3B - PubMed
6 hours ago
- #cccDNA
- #APOBEC3B
- #HBV
- hnRNPA2B1 promotes HBV cccDNA degradation by recruiting APOBEC3B.
- hnRNPA2B1 binds to G-quadruplex structures in cccDNA, particularly G4-1, G4-7, and G4-10.
- APOBEC3B induces C>T and G>A hypermutations, leading to cccDNA decay.
- HBV counteracts this mechanism via HBx-mediated hnRNPA2B1 polyubiquitination and degradation.
- The study identifies a potential therapeutic target for HBV infection.