Advances in the Development of Antibiotic Drug Candidates for Urinary Tract Infection Therapy - PubMed
11 hours ago
- #antibiotic resistance
- #UTI
- #E. coli
- Urinary tract infections (UTIs) are highly prevalent bacterial infections, with complications worsened by antibiotic resistance.
- Escherichia coli (E. coli) is the predominant pathogen, causing infections through adhesion and biofilm formation.
- Current antibiotics for UTI treatment include trimethoprim/sulfamethoxazole, nitrofurantoin, fosfomycin, ciprofloxacin, and others.
- Newly approved antibiotics, Orlynvah and Pivya, are discussed for their potential in UTI therapy.
- Structure-activity relationship (SAR)-guided development of trimethoprim derivatives and heterocyclic analogues targeting DHFR is explored.
- Nonantibiotic strategies like mannosides, curli inhibitors, and FimH antagonists are promising for anti-adhesion and biofilm-targeting therapies.
- The review highlights the urgent need for novel, resistance-resilient antibacterial agents in UTI prevention and therapy.